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[1] [2] As with any medication, understanding the full safety profile, including potential effects on renal health, is essential for appropriate patient counseling and monitoring

However, topiramate is currently used in combination with phentermine as an FDA-approved therapy for weight loss

Hepatology 64 , 20892102 (2016)

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It was found that the OPFRs only increased the level of ROS and methemoglobin at very high concentrations: at 500 g/mL, they were found to induce morphological changes and ultimately cause lytic cell death and PS externalization